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Herein is reported the development of a new process to manufacture ( S )-pregabalin. The method comprises six steps, run under the catalysis of a recyclable polymer bound phase transfer catalyst, and afforded ( S )-pregabalin in overall 54% yield, starting from building blocks acetylacetone, isovaleraldehyde, and nitromethane.
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Moccia et al. (2015) studied this question.
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