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March 1, 1997Journal of Analytical ToxicologyOpen Access

Comparison of Analytical Methods in the Determination of Two Venlafaxine Fatalities

Christopher Long J. A. Crifasi Diane Maginn Michael Graham Shaku Teas

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Abstract

Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 were 7.27 micrograms/mL venlafaxine and 5.03 micrograms/mL O-desmethylvenlafaxine, and Case 2 had 89.67 micrograms/mL venlafaxine with 3.44 micrograms/mL of the desmethyl metabolite. A comparison of analytical methods and specimen concentration is presented.

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Long et al. (1997) studied this question.

synapsesocial.com/papers/6aaf6521d85a37aba61107d2 https://doi.org/10.1093/jat/21.2.166

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