Key result
Antecedent recurrent hypoglycemia reduces severe hypoglycemic mortality by ~84% in insulin-deficient rats.
Why the study?
It was unknown whether chronic diabetes and insulin deficiency exacerbate, and whether recurrent antecedent hypoglycemia ameliorates, susceptibility to severe hypoglycemia-induced lethal cardiac arrhythmias.
Does antecedent recurrent hypoglycemia reduce severe hypoglycemia-induced fatal cardiac arrhythmias in diabetic rats?
RCT
Randomized into four groups
Does antecedent recurrent hypoglycemia reduce severe hypoglycemia-induced fatal cardiac arrhythmias in diabetic rats?
Effect estimate: 6.2-fold reduction
Absolute Event Rate: 5% vs 31%
In a rat model, severe hypoglycemia-induced cardiac arrhythmias and mortality were exacerbated by diabetes and insulin deficiency, but significantly attenuated by antecedent recurrent hypoglycemia.
No takes yet. Share an insight, caveat, or question.
Diabetes augments while antecedent hypoglycemia attenuates severe hypoglycemia-induced arrhythmias in rats; leaves open clinical relevance pending human data.
Reno et al. (2017) conducted an RCT in Diabetes and severe hypoglycemia-induced cardiac arrhythmias. Antecedent recurrent hypoglycemia vs. Streptozotocin-induced insulin deficiency (STZ) without recurrent hypoglycemia was evaluated on Mortality due to severe hypoglycemia (6.2-fold reduction). Antecedent recurrent hypoglycemia reduced mortality due to severe hypoglycemia to 5% compared to 31% in rats with streptozotocin-induced insulin deficiency.
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