Key result
Pomegranate extract moderately modulates miRs but surgical artifacts obscure clear dietary effects.
Why the study?
MicroRNAs are proposed as colorectal cancer biomarkers, but surgery critically alters their levels, complicating the discrimination of dietary effects and genuine tissue differences.
Does pomegranate extract consumption modify microRNA expression in colon tissues of colorectal cancer patients?
Comparison
Pomegranate extract 900 mg daily before surgery vs no pomegranate extract intake
Design
Randomized double-blind controlled trial
Follow-up
Before surgery
Authors
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Surgery confounds postoperative miR assessment in colorectal cancer; leaves open whether pomegranate extract modulates expression preoperatively.
RCT (n=45)
double-blind
randomized
Does pomegranate extract consumption modify microRNA expression in colon tissues of colorectal cancer patients?
Surgery critically alters microRNA levels in colon tissues, which confounds the assessment of dietary interventions like pomegranate extract on these biomarkers.
Núñez‐Sánchez et al. (2015) conducted an RCT in colorectal cancer (n=45). pomegranate extract vs. no pomegranate extract intake was evaluated on microRNAs (miRs) expression in surgical colon tissues versus biopsies. Pomegranate extract consumption moderately modulated various miRs, but surgery critically altered miRs levels, hindering the discrimination of dietary effects from surgical artefacts.
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