Key result
Daily timolol is linked to reduced fever severity and duration in acute MI.
Why the study?
The effect of beta-adrenoceptor blockade on the pyrexial response to acute myocardial infarction was studied to understand its potential clinical importance.
Does timolol reduce the pyrexial response in patients in the acute phase of acute myocardial infarction?
Observational (n=44)
Does timolol reduce the pyrexial response in patients in the acute phase of acute myocardial infarction?
Timolol significantly reduces the pyrexial response during the acute phase of myocardial infarction, which may help mitigate the risk of subsequent heart failure and arrhythmias.
Timolol-associated fever reduction in acute MI should not yet change practice; leaves open effects on HF/arrhythmias pending RCTs.
We have studied the effect of beta-adrenoceptor blockade on the pyrexial response to acute myocardial infarction (AMI). Temperatures of 22 patients treated with timolol, 20 mg daily, in the acute phase of AMI were compared to temperatures of 22 patients not receiving timolol treatment. Fever response after AMI was significantly reduced in the timolol-treated patients, maximal and mean temperature in the febrile period being lower and the febrile period being shorter. Reduction of fever in AMI may be of importance as a higher body temperature increases the risk of developing heart failure and arrhythmias. The study lends support to the use of beta-adrenoceptor blockade in AMI. It also substantiates a possible role of beta-adrenergic receptors in the regulation of body temperature during fever.
No takes yet. Share an insight, caveat, or question.
Risöe et al. (1986) conducted an observational in Acute myocardial infarction (AMI) (n=44). Timolol vs. No timolol treatment was evaluated on Pyrexial response (maximal and mean temperature, duration of febrile period). Timolol treatment (20 mg daily) significantly reduced the fever response, including maximal and mean temperature and duration of the febrile period, in patients with acute myocardial infarction.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: