Why the study?
Does early administration of timolol reduce infarct size in patients with acute myocardial infarction?
Population
144 patients admitted to the hospital within four hours after onset of symptoms of acute myocardial infarction
Comparison
Timolol given intravenously for the first 24… vs Placebo
Design
RCT, Randomly assigned
Follow-up
Duration of hospitalization
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Supports early timolol in acute MI to limit infarct size; confirms enzymatic and ECG-marker benefits in RCT.
Does early administration of timolol reduce infarct size in patients with acute myocardial infarction?
Early administration of intravenous followed by oral timolol in acute myocardial infarction significantly reduces infarct size and ischemic pain.
A 1984 study studied this question.
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