Key result
Late timolol fails to reduce infarct size, arrhythmias, or mortality after myocardial infarction.
Why the study?
The effects of relatively late oral timolol maleate administration after myocardial infarction on infarct size and arrhythmias were uncertain.
Does orally administered timolol maleate reduce infarct size and arrhythmias in patients with acute myocardial infarction when given relatively late?
RCT (n=88)
Double-blind
Does orally administered timolol maleate reduce infarct size and arrhythmias in patients with acute myocardial infarction when given relatively late?
Relatively late administration of oral timolol maleate (mean ~10.7 hours post-MI) does not reduce infarct size or arrhythmias in acute myocardial infarction.
Answers are grounded in this paper and cite their sources.
Early oral timolol post-MI yields no mortality, infarct size or arrhythmia benefit; challenges routine early use and leaves open optimal timing.
The effects of orally administered timolol maleate (10 mg twice a day) were assessed in 88 patients entered into a double-blind study within 10.74 +/- 5.07 hours of onset of myocardial infarction. Timolol maleate produced no significant change in crude mortality rate, infarct size, incidence of arrhythmias or significant left ventricular failure. Withdrawals from study because of recurrent angina or hypertension were confined to the placebo group. The results of this study suggested that, when given relatively late after infarction, timolol maleate does not reduce either infarct size or incidence of arrhythmias, despite production of a safe and effective beta-blockade.
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Tonkin et al. (1981) conducted an RCT in Acute myocardial infarction (n=88). Timolol maleate vs. Placebo was evaluated on Crude mortality rate, infarct size, incidence of arrhythmias, and significant left ventricular failure. Timolol maleate administered relatively late after myocardial infarction onset produced no significant change in infarct size, incidence of arrhythmias, or mortality compared to placebo.
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