Why the study?
Does early administration of timolol reduce infarct size and late ventricular tachycardia in patients with acute myocardial infarction?
Population
200 patients with acute myocardial infarction of less than 6 hours of evolution.
Comparison
Timolol 5.5 mg IV as a bolus divided into four… vs Matched placebo (IV bolus followed by oral).
Design
RCT, Assigned randomly
Follow-up
1 month
Authors
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Supports early timolol to limit infarct size in acute MI; extends beta-blocker evidence to enzymatic and VT endpoints.
Does early administration of timolol reduce infarct size and late ventricular tachycardia in patients with acute myocardial infarction?
Early administration of intravenous followed by oral timolol in acute myocardial infarction significantly reduces infarct size and the incidence of late ventricular tachycardia.
Roqué et al. (1987) studied this question.
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