Key result
Early treatment with timolol in acute anterior myocardial infarction significantly increased the occurrence of left ventricular apical thrombi compared to placebo (73.7% vs 25.0%, p<0.005).
Why the study?
Does early intervention with timolol increase the occurrence of left ventricular thrombi in patients with acute anterior myocardial infarction?
Population
40 patients with acute anterior myocardial infarction admitted to hospital within 6 hours of onset of…
Comparison
Intravenous followed by oral timolol maleate. vs Placebo.
Design
RCT, randomly assigned
Follow-up
10 days
Authors
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Early timolol warrants caution in acute anterior MI; challenges routine early beta-blocker use in this population.
RCT (n=40)
Does early intervention with timolol increase the occurrence of left ventricular thrombi in patients with acute anterior myocardial infarction?
Absolute Event Rate: 73.7% vs 25%
p-value: p=<0.005
Early administration of timolol in acute anterior myocardial infarction significantly increases the risk of left ventricular thrombus formation, likely due to reduced apical wall motion and heart rate.
Johannessen et al. (1987) conducted an RCT in Acute anterior myocardial infarction (n=40). Timolol vs. Placebo was evaluated on Occurrence of left ventricular apical thrombus detected by two-dimensional echocardiography from 2 to 10 days (p=<0.005). Early treatment with timolol in acute anterior myocardial infarction significantly increased the occurrence of left ventricular apical thrombi compared to placebo (73.7% vs 25.0%, p<0.005).
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