Key result
High insulin resistance linked to decreased endothelial function in nondiabetic predialysis CKD.
Why the study?
The association of insulin resistance and inflammation with vascular disease in nondiabetic predialysis CKD patients was unknown.
Population
35 nondiabetic predialysis stage 3-5 CKD patients and 35 age- and gender-matched controls
Comparison
Nondiabetic predialysis CKD patients vs age- and gender-matched controls
Design
Case-control study
Authors
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IR and inflammation independently associated with vascular dysfunction in nondiabetic predialysis CKD; hypothesis-generating, needs prospective confirmation before clinical implications.
Case-Control (n=70)
Effect estimate: adjusted β -0.44 (95% CI -1.55 to -0.08)
p-value: p=0.003
In nondiabetic predialysis CKD patients, insulin resistance and systemic inflammation are independently associated with endothelial dysfunction and atherosclerosis.
Banerjee et al. (2011) conducted a case-control in Nondiabetic predialysis chronic kidney disease (n=70). Insulin resistance (HOMA-IR) and systemic inflammation (hsCRP) vs. Lower levels of insulin resistance and inflammation was evaluated on Decreased brachial artery flow mediated dilation (FMD) (adjusted β -0.44, 95% CI -1.55 to -0.08, p=0.003). In nondiabetic predialysis CKD, high insulin resistance was independently associated with decreased endothelial function (adjusted β -0.44; 95% CI -1.55 to -0.08; P=0.003).
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