Reproductive Toxicity of Paraquat in Male Guinea Pig (Cavia porcellus)

This is the authors' abstract. We don't add key points for this paper.

Aims: This study was undertaken in order to evaluate the effects of paraquat (pesticide) on some reproductive parameters in male guinea pig.Methodology: Forty adult male guinea pigs averagely weighing 370.31 ± 39.43 g were distributed into 4 groups of 10 animals each, comparable in terms of body weight.During 42 days, each group of guinea pigs received by force-feeding either distilled water (control) or one of the following three doses of paraquat: 1.33, 2, 4 mg/kg of body weight.The effects of this pesticide were evaluted on some reproductive parameters (total cholesterol, libido, serum concentration of testosterone, weight of genital organs and characteristics of epididymal spermatozoa) and oxidative stress makers (testicular levels of MDA, SOD, CAT and GSH).