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October 11, 2025Tropical Journal of Pharmaceutical ResearchOpen Access

Structural and functional response of the genital tract to paraquat (PQ) dichloride exposure in female Wistar rats

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Authors

EEEhizokhale Santos EhebhaEAEfe Endurance AhamaEAEmmanuel Agbamu

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Overview

Experimental analysis reveals paraquat-induced ovarian atrophy and hormonal disruptions in Wistar rats, suggesting potential reproductive hazards.

Key Points

  • Paraquat exposure results in significant ovarian atrophy and chronic endometritis in female Wistar rats.
  • Serum levels of luteinizing hormone, follicle-stimulating hormone, estrogen, and progesterone significantly increased after paraquat treatment.
  • Exposure to paraquat disrupts the histoarchitecture of the reproductive tract, leading to severe functional alterations.
  • Further studies are needed to validate results and ensure regulatory guidelines for safe paraquat administration.

Cite This Study

Ehebha et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1b5ba7d64b6fc131e8ahttps://doi.org/10.4314/tjpr.v24i4.9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Histo-biochemical Assessment of Paraquat-induced Nephrotoxicity in Pregnant Wistar Rats and their Foetuses2025
  2. 2Sudachitin Alleviates Paraquat Instigated Testicular Toxicity in Albino Rats via Regulating Nrf‐2/Keap‐1, Inflammatory, Steroidogenic, and Histological Profile2024
  3. 3Investigating the impact of inhaled paraquat: A comprehensive evaluation protocol2024 · 2 citations
  4. 4Effect of Paraquat toxicity on lung and kidney organs on histopathological image assessment2024 · 1 citations
  5. 5Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels2026