Key result
Hypomagnesemia linked to ~2.3-fold higher odds of arrhythmias in chronic cardiovascular disease.
Why the study?
The point prevalence of hypomagnesemia in adults with chronic CVD and its associations with arrhythmias, LVEF, and exposure to commonly prescribed cardiovascular medications warranted estimation.
Is hypomagnesemia associated with an increased risk of arrhythmias and reduced left ventricular ejection fraction in adults with chronic cardiovascular disease?
Cross-Sectional (n=300)
No
Is hypomagnesemia associated with an increased risk of arrhythmias and reduced left ventricular ejection fraction in adults with chronic cardiovascular disease?
Hypomagnesemia is prevalent among patients with chronic cardiovascular disease—particularly those taking diuretics, PPIs, ACE inhibitors, or digoxin—and is independently associated with a higher odds of arrhythmias and lower LVEF.
Answers are grounded in this paper and cite their sources.
Hypomagnesemia may link to arrhythmias and lower LVEF in CVD; cross-sectional data leave causality and practice change open.
Purpose: To estimate the point prevalence of hypomagnesemia among adults with chronic cardiovascular disease (CVD) and its association with arrhythmias, left ventricular ejection fraction (LVEF), and exposure to commonly prescribed cardiovascular medications.Methods: This cross-sectional study was conducted at Al-Kindy Teaching Hospital, Baghdad, Iraq, from March 2023 to August 2024. The study included 200 adults with established CVD and 100 healthy controls. Serum magnesium was measured using a standardized colorimetric assay, with hypomagnesemia defined as < 1.8 mg/dL. Arrhythmias were assessed by 12-lead electrocardiography and LVEF by transthoracic echocardiography. Medication exposure was obtained from medical records and patient interviews.Results: Hypomagnesemia was significantly more prevalent among patients with CVD compared with controls (p < 0.001) and independently associated with arrhythmias (odds ratio [OR] = 2.3; 95 % confidence interval [CI]: 1.4 – 3.8; p = 0.001). Each 0.1 mg/dL decrease in serum magnesium was associated with a 0.15 % reduction in LVEF (β = −0.15; 95 % CI: −0.25 to −0.05; p = 0.002). Furthermore, hypomagnesemia was more frequent among users of diuretics, proton pump inhibitors, angiotensin-converting enzyme inhibitors, and digoxin.Conclusion: Hypomagnesemia was common among patients with CVD, and independently associated with arrhythmias.
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Al-Doori et al. (2026) conducted a cross-sectional in Chronic cardiovascular disease (n=300). Hypomagnesemia (serum magnesium < 1.8 mg/dL) vs. Normomagnesemia / healthy controls was evaluated on Arrhythmias assessed by 12-lead electrocardiography (OR 2.3, 95% CI 1.4-3.8, p=0.001). Hypomagnesemia (<1.8 mg/dL) was independently associated with arrhythmias in adults with chronic cardiovascular disease (OR 2.3; 95% CI 1.4-3.8; p=0.001).
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