Key result
Inactivated Marek's disease antigen vaccination protects bursectomised chickens independently of a humoral immune response.
Why the study?
The mechanisms of immunity induced by vaccination with inactivated Marek's disease virus-specific antigens in bursectomised chickens were unclear.
Vaccination with inactivated Marek's disease virus-specific antigens protects bursectomised chickens against the disease, suggesting immunity is not dependent on a humoral immune response.
Supports non-humoral immunity in viral protection; leaves open translation to other species or vaccines.
Bursectomised chickens were protected against Marek's disease (MD) by vaccination with inactivated MD virus-specific antigens. The immunity was associated with lowered lymphocyte-associated MD viraemia following challenge. Evidence is presented that the immunity was not dependent on a humoral immune response but possibly on the presence of lymphocytes sensitised to virus-specific antigens.
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Payne et al. (1978) studied this question. Vaccination with inactivated Marek's disease virus-specific antigens protected bursectomised chickens against Marek's disease independently of a humoral immune response.
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