Key result
Serum pre-albumin >0.16 g/L is linked to ~76% lower MACE risk in elderly CHF patients.
Why the study?
The clinical value of blood pre-albumin and NT-pro BNP levels in prognosis evaluation of elderly patients with chronic heart failure was unclear.
Do blood pre-albumin and NT-pro BNP levels predict major adverse cardiac events in elderly patients hospitalized for chronic heart failure?
Cohort (n=410)
No
Do blood pre-albumin and NT-pro BNP levels predict major adverse cardiac events in elderly patients hospitalized for chronic heart failure?
Odds Ratio: 0.242 (95% CI 0.137–0.406)
Absolute Event Rate: 37.61% vs 79.14%
p-value: p=<0.001
Lower serum pre-albumin and higher NT-pro BNP levels are independent predictors of major adverse cardiac events in elderly patients hospitalized for chronic heart failure.
May support pre-albumin for MACE risk stratification in elderly HF; hypothesis-generating and needs prospective validation.
Levels of blood pre-albumin (PA) and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) in elderly patients with chronic heart failure (CHF) and their clinical value in prognosis evaluation were explored. A total of 410 elderly patients aged ≥65 years hospitalized for CHF were enrolled. The concentrations of blood PA and NT-pro BNP, routine blood test and biochemistry indicators were determined and color Doppler echocardiography was performed. Additionally, the patients were followed up after discharge, and based on the occurrence of major adverse cardiac events (MACE), they were divided into MACE group and non-MACE group. MACE group had an older age and a higher level of plasma NT-pro BNP than non-MACE group (77.82±6.57) years vs. (76.39±6.18) years, and (8,864.52±9,718.36) pg/ml vs. (4,165.62+6,437.28) pg/ml (P<0.05), and the left ventricular ejection fraction and serum PA level in MACE group were lower than those in non-MACE group (P<0.05). According to the results of multivariate regression analysis, serum PA [odds ratio (OR)=0.242, 95% confidence interval (CI)=0.137-0.406, P<0.001] and plasma NT-pro BNP (OR=1.847, 95% CI=1.024-3.158, P=0.036) were independent risk factors for the occurrence of cardiac events during follow-up. Decline in PA level and elevation in NT-pro BNP level have a strong correlation with poor prognosis of elderly CHF patients, and they can be used for clinically evaluating disease conditions, guiding treatment and improving prognosis.
No takes yet. Share an insight, caveat, or question.
Shi et al. (2020) conducted a cohort in Chronic heart failure (n=410). Serum pre-albumin (PA) >0.16 g/l vs. Serum pre-albumin (PA) ≤0.16 g/l was evaluated on Major adverse cardiac events (MACE) (OR 0.242, 95% CI 0.137-0.406, p=<0.001). Serum pre-albumin levels >0.16 g/l were independently associated with a significantly lower risk of major adverse cardiac events (OR 0.242) compared to levels ≤0.16 g/l in elderly patients with chronic heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: