Key result
Myomasp/LRRC39 knockdown impairs force generation and heart function in engineered tissue and zebrafish.
Why the study?
The exact molecular composition of the sarcomeric M-band and its specific proteins remain unclear, with few M-band-specific proteins identified to date.
Population
Neonatal rat ventricular myocytes, engineered heart tissue constructs, and zebrafish models
Comparison
Knockdown of myomasp/LRRC39 vs control
Design
Preclinical experimental study
Authors
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Myomasp/LRRC39 identifies a novel stretch-sensing pathway in models; hypothesis-generating for human cardiomyopathy mechanisms and therapies.
Myomasp/LRRC39 is a novel M-band protein involved in stretch sensing, and its downregulation leads to impaired cardiac function and cardiomyopathy in preclinical models.
Will et al. (2010) studied this question. Knockdown of myomasp/LRRC39 was evaluated on Heart function, force generation, and fractional shortening. Knockdown of the novel M-band protein myomasp/LRRC39 in engineered heart tissue and zebrafish resulted in significantly lower force generation, reduced fractional shortening, and impaired heart function.
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