Key result
Subclinical atherosclerosis affects ~58% of newly diagnosed T2DM cases and weakly correlates with diabetic retinopathy.
Why the study?
The clinical features and related risk factors of diabetic retinopathy and subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus were not well characterized.
What are the clinical features and related risk factors for diabetic retinopathy and subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus?
Observational (n=435)
What are the clinical features and related risk factors for diabetic retinopathy and subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus?
Effect estimate: r=0.098
p-value: p=0.041
Subclinical atherosclerosis is highly prevalent in newly diagnosed T2DM and correlates with diabetic retinopathy, emphasizing the need for early screening and dyslipidemia management.
PURPOSE: To analyze the clinical features and related risk factors in diabetic retinopathy (DR) and subclinical atherosclerosis, the micro- and macro-vascular diseases in newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: A retrospective study of 435 cases of inpatients with newly diagnosed T2DM from 2013-2017, and compare the 2 types of T2DM related vascular complications. RESULTS: The macro- and microvascular complications are not rare at this stage. Subclinical atherosclerosis was found in 251 subjects (57.7%), which was higher than that of DR (13.1%). In addition, some cases of subclinical atherosclerosis co-existed with DR, suggesting that DR was related with subclinical atherosclerosis (r=0.098, P=0.041). Older age showed a significant association with both subclinical atherosclerosis and DR. Single factor analysis indicated that dyslipidemia was the common risk factor in DR and subclinical atherosclerosis. CONCLUSIONS: It should be paid attention to the screening of both DR and subclinical atherosclerosis in each age group of newly diagnosed T2DM. Except for the control of blood glucose, the control of the dyslipidemia is important in the prevention and treatment of the micro- and macro-vascular diseases.
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Guo et al. (2019) conducted an observational in newly diagnosed type 2 diabetes mellitus (n=435). Risk factors (older age, dyslipidemia) was evaluated on Correlation between diabetic retinopathy and subclinical atherosclerosis (r=0.098, p=0.041). Subclinical atherosclerosis (57.7%) and diabetic retinopathy (13.1%) were correlated in newly diagnosed T2DM (r=0.098, P=0.041), with older age and dyslipidemia identified as common risk factors.
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