Key result
Ambrisentan is linked to improved pulmonary hemodynamics in exercise PH but decreased oxygen extraction limits VO2max.
Why the study?
Ambrisentan improves pulmonary hemodynamics in exercise pulmonary hypertension, but its effect on maximum oxygen uptake and systemic oxygen extraction is unclear.
Does ambrisentan improve pulmonary hemodynamics and maximum oxygen uptake in patients with exercise-induced pulmonary hypertension?
Observational (n=22)
Does ambrisentan improve pulmonary hemodynamics and maximum oxygen uptake in patients with exercise-induced pulmonary hypertension?
In patients with exercise-induced pulmonary hypertension, ambrisentan improves pulmonary hemodynamics but may unmask a pre-existing skeletal muscle abnormality that blunts improvements in maximum oxygen uptake.
Does not support ambrisentan for ePH; hypothesis-generating for skeletal muscle limits on exercise capacity.
Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO2max) secondary to decreased maximum exercise systemic oxygen extraction (Ca‐vO2). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre‐existing skeletal muscle abnormality.
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Faria‐Urbina et al. (2018) conducted an observational in pulmonary hypertension diagnosed during exercise (ePH) (n=22). Ambrisentan was evaluated on pulmonary hemodynamics and maximum oxygen uptake (VO2max). Ambrisentan improved pulmonary hemodynamics in patients with exercise pulmonary hypertension, but showed only a trend toward increased maximum oxygen uptake due to decreased systemic oxygen extraction.
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