Key result
Five OAS2 and OAS3 SNPs linked to central nervous system disease in tick-borne encephalitis.
Why the study?
The association between variability in the 2'-5'-oligoadenylate synthetase gene cluster and human predisposition to tick-borne encephalitis virus-induced disease was investigated.
Observational (n=142)
Specific single nucleotide polymorphisms in the OAS2 and OAS3 genes are associated with the severity of tick-borne encephalitis virus infection in a Russian population.
The 2'-5'-oligoadenylate synthetase (2'-5'-OAS) family members are interferon-induced antiviral proteins. Twenty-three single nucleotide polymorphisms located within the OAS1, OAS2, OAS3, and OASL genes were analyzed in 142 patients with Russian tick-borne encephalitis. Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group. The data suggest a possible association between these 5 OAS single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.
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Barkhash et al. (2010) conducted an observational in Tick-borne encephalitis (n=142). OAS gene cluster single nucleotide polymorphisms vs. Control group was evaluated on Differences in genotype, allele, and haplotype frequencies. Five single nucleotide polymorphisms in the OAS2 and OAS3 genes were significantly associated with central nervous system disease in patients with tick-borne encephalitis.
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