Non-Canonical WNT Pathway in Breast Cancer and Breast Cancer StemCell Signalling

Breast cancer is the most common cancer in women all over the world.Though various treatment regimens are available for breast cancer, treatment of breast tumor is still a challenge.Breast cancer can be of different types and like many other cancers, it is a stem cell disease.Presence of stem cell might be the cause of therapy failure due to their characteristic feature of drug resistance.So researchers now focus in regulating breast Cancer Stem Cells (brCSCs).Wnt signalling is a major signalling pathway involved in regulating tumour morphogenesis.Wnt signalling pathways have been categorized into: canonical Wnt pathway and non-canonical Wnt pathway.Both canonical and non-canonical pathways play major role in maintenance of stemness in brCSCs.Since canonical pathway of Wnt signalling has been studied in great detail, studying non-canonical pathway and its signalling mechanisms will provide interesting insights to control breast cancer and its stemness properties.This review will focus on the recent and the various research aspects on the non-canonical pathway in regulating brCSCs.