Key result
Treat-and-repair strategy using PAH therapy and fenestrated closure improves hemodynamics in an Eisenmenger syndrome patient.
Why the study?
The potential utility of a treat-and-repair strategy in patients with Eisenmenger syndrome and severe pulmonary arterial hypertension who respond to medical therapy is not well established.
Does a treat-and-repair strategy improve symptoms and hemodynamics in a patient with Eisenmenger syndrome and severe PAH due to ASD?
Case Report (n=1)
No
Does a treat-and-repair strategy improve symptoms and hemodynamics in a patient with Eisenmenger syndrome and severe PAH due to ASD?
A treat-and-repair strategy involving PAH-specific medical therapy followed by surgical closure may be effective for select patients with Eisenmenger syndrome due to ASD.
May support individualized treat-and-repair in select ES; leaves open need for prospective trials on eligibility and outcomes.
A 53-year-old man with Eisenmenger syndrome (ES), caused by a large secundum atrial septal defect (ASD) and severe pulmonary arterial hypertension (PAH), showed a marked hemodynamic improvement following an escalation of PAH-specific therapy. Surgical ASD closure using a fenestrated patch was successfully performed after a significant reduction in both the patient's pulmonary pressure and vascular resistance. This case highlights the potential utility of the "treat-and-repair" strategy in patients with ES and severe PAH, who exhibit a favorable response to medical therapy, resulting in both a symptomatic and hemodynamic improvement.
No takes yet. Share an insight, caveat, or question.
Kadota et al. (2026) conducted a case report in Atrial Septal Defect with Eisenmenger Syndrome due to Pulmonary Arterial Hypertension (n=1). Treat-and-repair strategy (PAH-specific medical therapy followed by surgical ASD closure) was evaluated on Hemodynamic and symptomatic improvement. A treat-and-repair strategy involving aggressive PAH-specific medical therapy followed by fenestrated surgical closure successfully improved hemodynamics and symptoms in a patient with Eisenmenger syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: