Key result
MDV2 genome sequencing reveals 12 complete ORFs and distinct transcriptional patterns versus MDV serotype 1.
Why the study?
Studies on Marek's disease virus serotype 2 are important for understanding the natural nonpathogenic phenotypes of MDV.
The study maps the UL41 to UL51 gene homologues in MDV2, revealing transcriptional differences from MDV1 that may relate to its nonpathogenic phenotype.
Advances MDV2 genomics; extends alphaherpesvirus collinearity but leaves open functional validation.
Studies on Marek's disease virus serotype 2 (MDV2) are important for understanding the natural nonpathogenic phenotypes of MDV. We determined the 16770 bp nucleotide sequence of the MDV2 genome located in the right part the of unique long region. The analysis revealed 12 complete open reading frames (ORFs) with high amino acid sequence identities to the gene products of other alphaherpesviruses. The MDV2 ORFs were arranged collinearly with the prototype sequence of herpes simplex virus type 1 ranging from the UL41 to UL51 genes. Except for the MDV2 UL41 gene, all of the identified genes were confirmed to be transcribed with 3'-coterminal mRNAs and/or a unique transcript in the virus-infected cells. Transcriptional patterns for the regions of the MDV2 UL48 to UL49.5 genes were notably different from the similar area of MDV serotype 1.
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Izumiya et al. (1998) studied Marek's disease virus serotype 2 (MDV2). Analysis of the 16770 bp MDV2 genome revealed 12 complete ORFs collinear with HSV-1 UL41 to UL51, with transcriptional patterns for UL48 to UL49.5 differing notably from MDV serotype 1.
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