Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C

Elena García‐Martín; José A. G. Agúndez; M. L. Maestro; Avelina Suárez; Marta Vidaurreta; Carmen Martínez; Cristina Fernández; Luís Ortega; José M. Ladero

doi:10.1371/journal.pone.0074764

September 20, 2013PLoS ONEOpen Access

Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C

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Key Points

To assess whether single nucleotide polymorphisms in vitamin D-related genes (CYP27B and VDR) influence response to pegylated interferon and ribavirin antiviral therapy in patients with chronic hepatitis C.
Genotyped single nucleotide polymorphisms in CYP27B-1260 (rs10877012AC) and VDR (rs2228570TC, rs1544410CT, rs7975232AC, rs731236AT) in 238 Caucasian chronic hepatitis C patients treated with pegylated interferon plus ribavirin.
Conducted multivariate analyses controlling for established baseline response predictors including HCV genotype, viral load, IL28B genotype, age, GGT, and serum cholesterol.
The VDR CCA haplotype across rs1544410, rs7975232, and rs731236 independently predicted therapeutic failure (OR 2.743, 95% CI 1.313–5.731, p = 0.007).
Carrying the VDR rs2228570 T allele was inversely related to therapeutic failure (OR 0.438, 95% CI 0.204–0.882, p = 0.021), whereas CYP27B-1260 rs10877012 showed no significant association.
The multivariable prediction model incorporating significant demographic, virologic, biochemical, and genetic variables achieved an AUROC of 0.846 (95% CI 0.793–0.899).

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Implication

Cohort study reveals vitamin D receptor gene variants influence antiviral response in chronic hepatitis C, indicating their value as predictive biomarkers.

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García‐Martín et al. (2013) studied this question.

synapsesocial.com/papers/6aaf738bc3eca59fee25d6eb https://doi.org/10.1371/journal.pone.0074764

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Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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