High‐Contrast Imaging of α‐Synuclein Pathologies in Living Patients with Multiple System Atrophy

Kiwamu Matsuoka; Maiko Ono; Yuhei Takado; Kosei Hirata; Hironobu Endo; Toshiyuki Ohfusa; Taichi Kojima; Takeshi Yamamoto; Tomohiro Onishi; Asumi Orihara; Kenji Tagai; Keisuke Takahata; Chie Seki; Hitoshi Shinotoh; Kazunori Kawamura; Hiroshi Shimizu; Hitoshi Shimada; Akiyoshi Kakita; Ming‐Rong Zhang; Tetsuya Suhara; Makoto Higuchi

doi:10.1002/mds.29186

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Abstract

Multiple system atrophy (MSA) is a neurodegenerativedisorder characterized by glial cytoplasmic inclusions(GCIs)1composed ofα-synuclein aggregates as neuropatho-logical hallmarks.2In vivo visualization ofα-synucleinpathologies potentially offers diagnostic assessments ofMSA, but has been challenging because of the lack of sensi-tive imaging agents.

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Matsuoka et al. (2022) studied this question.

synapsesocial.com/papers/6aaf74fec8a40e211910f979 https://doi.org/10.1002/mds.29186

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High‐Contrast Imaging of α‐Synuclein Pathologies in Living Patients with Multiple System Atrophy

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High‐Contrast Imaging of α‐Synuclein Pathologies in Living Patients with Multiple System Atrophy

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