Key result
Analytical approaches account for treatment effect differences across study centers in multicenter RCTs.
Why the study?
Analytical approaches to account for differences in treatment effect by study center in multicenter randomized trials require clarification.
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Design
Guide to statistics and methods discussing multicenter randomized clinical trials
Enables robust interpretation of multicenter trial results; extends statistical methods for handling center-level treatment heterogeneity.
This Guide to Statistics and Methods discusses analytical approaches to accounting for differences in treatment effect by study center when randomized trials enroll patients and administer interventions at multiple sites.
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Senn et al. (2019) studied this question. Analytical approaches for multicenter randomized clinical trials provide methods to account for differences in treatment effects across various study centers.
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