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After routine examination of a surgically removed thyroid nodule from a young female with a family history of amyloidosis, special stains for the identification of amorphous eosinophilic deposits in the vasculature were performed. These congophilic deposits, which exhibited typical apple-green birefringence resistant to permanganate treatment, were reactive when immunostained with transthyretin (prealbumin) antibody. A subsequent endomyocardial biopsy revealed deposits with the identical histochemical properties. (The Histotechnol 15:325, 1992)
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Ippolito et al. (1992) studied this question.
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