Key result
Primary thyroid synovial sarcoma presents with extensive invasion and fatal metastasis within 2 months.
Why the study?
Primary synovial sarcoma of the thyroid gland is an extremely rare and aggressive condition with limited reported cases.
Case Report (n=1)
Primary synovial sarcoma of the thyroid is an extremely rare, highly aggressive tumor that requires early diagnosis and comprehensive treatment.
Case of rapidly fatal primary thyroid synovial sarcoma; hypothesis-generating for earlier detection and effective therapies.
Primary synovial sarcoma of the thyroid is an extremely rare condition which has only been reported twice in the literature. We herein report a case of highly aggressive and rapidly lethal primary synovial sarcoma of the thyroid. A 72-year-old woman presented with extensive local invasion, rapid progression, and early distant metastasis secondary to primary thyroid synovial sarcoma. The tumor exhibited an atypical histologic and immunohistochemical staining pattern. Detection of SYT/SSX fusion transcript confirmed the diagnosis of synovial sarcoma. Due to the aggressive nature of primary synovial sarcoma of the thyroid gland, early diagnosis and comprehensive treatment including wide resection and postoperative chemoradiation is required.
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Ryu et al. (2011) conducted a case report in Synovial sarcoma of the thyroid gland (n=1). Total thyroidectomy with tracheal fenestration was evaluated. A 72-year-old woman with primary synovial sarcoma of the thyroid gland presented with extensive local invasion and early distant metastasis, and died 2 months after palliative surgery.
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