Key result
Total thyroidectomy plus chemotherapy achieves 1-year recurrence-free survival in a pediatric thyroid synovial sarcoma case.
Why the study?
Primary synovial sarcoma of the thyroid gland is a rare and aggressive neoplasm with difficult early diagnosis and no defined treatment regimens due to its rarity.
Case Report (n=1)
No
Primary synovial sarcoma of the thyroid is extremely rare, especially in children under 5, but can be successfully treated with total thyroidectomy and adjuvant chemotherapy.
Supports multimodality therapy feasibility in rare pediatric thyroid synovial sarcoma; hypothesis-generating and leaves optimal management open.
Primary Synovial sarcoma of the thyroid gland is a rare sarcoma. We report a case of synovial sarcoma of the thyroid gland in a 2-yr-old boy presenting with a palpable progressively increasing neck mass, high resolution ultrasound revealed a heterogeneous lesion measuring 5 x 4 cm identified in the right lobe compressing the left lobe. A total thyroidectomy was performed and grossly both the lobes were involved. Histologically, the tumor was a biphasic synovial sarcoma which was confirmed by immunohistochemical markers showing positive expression for vimentin, Epithelial membrane antigen &Transducin-like enhancer of split-1. This is an unusual location for the occurrence of primary synovial sarcoma and aggressive nature the early diagnosis is difficult, and no definite treatment regimens are being defined due to the rarity of neoplasm.
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Srivastava et al. (2020) conducted a case report in Primary synovial sarcoma of the thyroid gland (n=1). Total thyroidectomy and chemotherapy was evaluated on Recurrence. Total thyroidectomy followed by 6 cycles of doxorubicin and ifosfamide resulted in no signs of recurrence after 1 year of follow-up in a 2-year-old boy with primary synovial sarcoma of the thyroid.
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