December 1, 1998Annals of Otology Rhinology & Laryngology
Synovial Sarcoma of the Larynx and Hypopharynx
Key result
Cytogenetic analysis detects diagnostic X-18 chromosome aberrations in two laryngeal and hypopharyngeal synovial sarcoma cases.
- n=2
Why the study?
Synovial sarcoma is a rare mesenchymal malignancy in the head and neck region, with limited data on cases arising in the larynx and hypopharynx.
Comparison
Cytogenetic analysis detecting t(X;18) chromosome aberration
Design
Case report
Authors
Discussion
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Implication
May support t(X;18) testing for rare laryngeal synovial sarcoma; leaves open prospective validation.
Study Design
Type
Case Report (n=2)
Structured PICO
P
Population
Two cases of synovial sarcoma arising in the larynx and hypopharynx.
E
Exposure
Cytogenetic analysis
O
Outcome
Detection of t(X;18) chromosome aberration
Cytogenetic analysis detecting the t(X;18) translocation can aid in the diagnosis of rare synovial sarcomas of the larynx and hypopharynx.
Cite This Study
Tos et al. (1998) conducted a case report in Synovial sarcoma of the larynx and hypopharynx (n=2). Cytogenetic analysis was evaluated on Detection of t(X;18) chromosome aberration. Cytogenetic analysis detected a diagnostic t(X;18) chromosome aberration in two cases of synovial sarcoma arising in the larynx and hypopharynx.