Key result
Hypertension with diabetes is linked to higher CFPWV versus hypertension alone or healthy controls.
Why the study?
Arterial stiffness is an independent predictor for vascular diseases, and the study investigated risk factors involving carotid-femoral pulse wave velocity in hypertension and diabetes mellitus subjects.
Cross-Sectional (n=425)
No
Answers are grounded in this paper and cite their sources.
The combination of hypertension and diabetes mellitus is associated with significantly higher arterial stiffness compared to either condition alone or healthy controls.
Background: Arterial stiffness is an independent predictor for vascular diseases. Carotid-femoral pulse wave velocity (CFPWV) is a reliable index of arterial stiffness. In the present study, we investigated the possible risk factors involving CFPWV in hypertension and diabetes mellitus (DM) subjects.Methods: 425 subjects (M/F 168/257) from Shougang Corporation Examination Center were divided into four groups: healthy group (n=185), hypertension group (n=135), DM group (n=32), hypertension with DM group (n=73). CFPWV was measured by Complior apparatus.Results: Our results showed that CFPWV was significantly higher in hypertension subjects with DM than in healthy and hypertension group, respectively (12.00+2.57 vs 10.12+2.28 m/s; 12.00+2.57 vs 10.78+2.07 m/s, both p<0.05). CFPWV was positively correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), fasting plasma glucose ( FBG), HbA1c, uric acid, Log NT-proBNP and Log Urine Albumin (microalbumin) Excretion [Log UAE] in the entire group(r=0.437, 0.410, 0.206, 0.423, 0.210, 0.275, 0.130, 0.135, 0.166, all p<0.05, respectively). Multivariate analysis showed that age, body mass index, SBP, PP, FBG were independent associating factors of CFPWV in all subjects (β=0.287, p<0.001; β= -0.194, p=0.003; β=0.223, p=0.001; β=0.293, p<0.001; β=0.161, p=0.008; respectively).Conclusions: Our present study suggested that CFPWV was significantly higher in hypertension subjects with DM compared to healthy and hypertension groups.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2016) conducted a cross-sectional in Hypertension and diabetes mellitus (n=425). Hypertension with diabetes mellitus vs. Healthy group and hypertension-only group was evaluated on Carotid-femoral pulse wave velocity (CFPWV) (p=<0.05). Hypertension with diabetes mellitus was associated with significantly higher carotid-femoral pulse wave velocity (12.00 m/s) compared to healthy (10.12 m/s) and hypertension (10.78 m/s) groups (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: