Key result
Diabetes in hypertensive patients is linked to ~16% higher CF-PWV and lower ABI.
Why the study?
The study was conducted to investigate the relationship between ankle-brachial index and carotid-femoral pulse wave velocity in patients with hypertension and diabetes mellitus.
Cross-Sectional (n=1,577)
No
In patients with hypertension, the presence of diabetes mellitus is associated with higher arterial stiffness (CF-PWV) and lower ankle-brachial index, with CF-PWV being an independent associating factor of ABI.
Answers are grounded in this paper and cite their sources.
Associated with greater stiffness and lower ABI in hypertensive diabetes; leaves open causal and prognostic implications.
Background: Ankle-brachial index (ABI) is used to diagnose peripheral artery disease. Arterial stiffness could be measured by carotid-femoral pulse wave velocity (CF-PWV). The study was to investigate relationship between ABI and CF-PWV in patients with hypertension and diabetes mellitus. Methods: 1577 patients (M/F 812/765) from Department of Vascular Medicine were enrolled. ABI was recorded by VaseraVS-1000 vascular screening system (Fukuda Denshi, Tokyo, Japan). CF-PWV was recorded by Complior apparatus. Results: CF-PWV was significantly higher in hypertension patients with diabetes mellitus than hypertension patients without diabetes mellitus (13.77 ± 3.91 vs 11.83 ± 3.26 m/s, p < 0.05). Right ABI was significantly lower in hypertension patients with diabetes mellitus than hypertension patients without diabetes mellitus (1.062 ± 0.163 vs 1.102 ± 0.105, p < 0.05). Right ABI was negatively correlated with age, systolic blood pressure, CF-PWV and creatinine in entire study group (r = -0.081, p = 0.001; r = -0.069,p < 0.001; r = -0.178, p < 0.001; r = -0.124, p < 0.001, respectively). Multiple linear regressions found that CF-PWV, body mass index (BMI), gender, creatinine, total cholesterol, uric acid and diabetes mellitus were independent associating factors of RABI in all patients (β = -0.168, p < 0.001; β = 0.180, p < 0.001; β = -0.189, p < 0.001; β = -0.102, p = 0.008; β = 0.088, p = 0.004; β = -0.100, p = 0.009;β = -0.062, p = 0.043; respectively). CF-PWV, BMI, gender and HDL-C were independent associating factors of left ABI in all patients (β = -0.170, p < 0.001; β = 0.172, p < 0.001; β = -0.104, p = 0.001; β = 0.074, p = 0.023; respectively). Conclusions: ABI was significantly lower in hypertension patients with diabetes mellitus, with higher level of CF-PWV. CF-PWV was an independent associating factor of ABI, indicating the greater the elasticity of the large arteries, the higher the probability of lower limb artery occlusion.
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Liu et al. (2025) conducted a cross-sectional in Hypertension and diabetes mellitus (n=1,577). Hypertension with diabetes mellitus vs. Hypertension without diabetes mellitus was evaluated on Carotid-femoral pulse wave velocity (CF-PWV) in m/s (p=<0.05). Hypertension patients with diabetes mellitus had significantly higher carotid-femoral pulse wave velocity (13.77 vs 11.83 m/s) and lower right ankle-brachial index (1.062 vs 1.102) than those without diabetes.
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