Key result
Novel equation corrects measurement lag in flow-through physiological experiments to improve response accuracy.
Why the study?
Physiological experiments using flow-through or open systems may produce biased results due to lag between actual organism response and measured system response.
Presents a mathematical adjustment for lag in flow-through physiological systems to improve measurement accuracy of time-dependent rates.
Answers are grounded in this paper and cite their sources.
Lag adjustment prevents biased rate estimates in open systems; extends precision for time-dependent physiological measurements.
The results from physiological experiments that use a flow-through or open system may be biased because of lag. The nature of this discrepancy is attributable to a delay between the actual response of an organism and the measured response of the system. An equation is presented that would adjust the measurement for lag. This procedure is especially important when measuring time-dependent uptake and depuration rates like those reported in respiratory and toxicological studies.
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A. J. Niimi (1978) studied this question. Lag adjustment equation was evaluated. An equation is presented to adjust measurements for lag in physiological experiments using flow-through systems, correcting for the delay between actual and measured responses.
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