Key result
Higher PLA2s-IIE and -V expression correlates with greater human aortic valve calcification.
Why the study?
The role of phospholipase A2 enzymes in human aortic valve calcification and their relationship with osteogenic molecule expression was unclear.
Does the inhibition of PLA2s-IIE and -V suppress the induction of osteogenic molecules in human valve interstitial cells?
Observational (n=38)
No
Does the inhibition of PLA2s-IIE and -V suppress the induction of osteogenic molecules in human valve interstitial cells?
Effect estimate: ρ=0.66 for PLA2-IIE and ρ=0.43 for PLA2-V
p-value: p=<0.01
PLA2s-IIE and -V are associated with aortic valve calcification and their inhibition suppresses pro-osteogenic molecules in vitro, suggesting a potential therapeutic target for valve calcification.
No takes yet. Share an insight, caveat, or question.
May support PLA2s-IIE/V as targets in valve calcification; hypothesis-generating from Level 5 data and requires human validation.
Suzuki et al. (2014) conducted an observational in Aortic valve calcification (n=38). Expression of PLA2s-IIE and -V was evaluated on Correlation between the grade of valve calcification and the degree of immunoreactivity for PLA2-IIE and -V (ρ=0.66 for PLA2-IIE and ρ=0.43 for PLA2-V, p=<0.01). The expression of PLA2s-IIE and -V significantly correlated with the grade of calcification in human aortic valves (ρ=0.66 and 0.43, respectively, p<0.01).
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