Key result
Co-administering RIX4414 with routine vaccines achieves ~64% seroconversion without interfering with routine vaccine responses.
Why the study?
The immunogenicity and reactogenicity of the human rotavirus vaccine RIX4414 when co-administered with routine childhood vaccines in Chinese infants required evaluation.
Does co-administration of the human rotavirus vaccine (RIX4414) with routine childhood vaccines affect immunogenicity and reactogenicity in healthy Chinese infants?
RCT (n=786)
Does co-administration of the human rotavirus vaccine (RIX4414) with routine childhood vaccines affect immunogenicity and reactogenicity in healthy Chinese infants?
Absolute Event Rate: 64.2% vs 74.7%
Co-administration of the human rotavirus vaccine RIX4414 with routine childhood vaccines in Chinese infants is well-tolerated and does not interfere with the immunogenicity of the routine vaccines.
Supports co-administration of RIX4414 with DTPa/OPV in Chinese infants; leaves open confirmation via larger efficacy trials.
This study evaluated the immunogenicity of the human rotavirus (RV) vaccine (RIX4414) when co-administered with routine childhood vaccines in Chinese infants (NCT01171963). Healthy infants aged 6-16 weeks received 2 doses of either RIX4414 or placebo according to a 0, 1-month schedule. Infants received routine diphtheria-tetanus-acellular pertussis (DTPa) and oral poliovirus (OPV) vaccines either separately from or concomitantly with RIX4414/placebo (separate and co-administration cohorts, respectively). Anti-RV IgA seroconversion rates (one month post-dose-2) and seropositivity rates (at one year of age) were measured using ELISA. Immune responses against the DTPa and OPV antigens were measured one month post-DTPa dose-3 in the co-administration cohort. Solicited local and general symptoms were recorded for 8-days post-vaccination (total cohort). The according-to-protocol immunogenicity population included 511 infants in the separate cohort and 275 in the co-administration cohort. One month post-RIX4414 dose-2, anti-RV IgA seroconversion rates were 74.7% (95% confidence interval [CI]: 68.9-79.9) and 64.2% (95% CI: 55.4-72.3) in the separate and co-administration cohorts; seropositivity rates at one year of age were 71.5% (95% CI: 65.5-77.1) and 50.0% (95% CI: 40.9-59.1), respectively. One month post-DTPa dose-3, all infants in the co-administration cohort were seroprotected against diphtheria and tetanus, and seropositive for pertussis toxoid, pertactin and filamentous haemaglutinin. Two months post-OPV dose-3, seroprotection rates against anti-poliovirus types 1, 2 and 3 were >99% in the co-administration cohort. Reactogenicity profiles were similar in both cohorts. RIX4414 was immunogenic and well-tolerated in Chinese infants and did not appear to interfere with the immunogenicity and reactogenicity of co-administered routine childhood vaccines.
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Li et al. (2015) conducted an RCT in Healthy infants (n=786). RIX4414 co-administered with routine childhood vaccines vs. RIX4414 administered separately from routine childhood vaccines was evaluated on Anti-RV IgA seroconversion rates one month post-dose-2. Co-administration of the RIX4414 rotavirus vaccine with routine childhood vaccines was immunogenic (64.2% seroconversion vs 74.7% separately) and did not interfere with routine vaccine responses.
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