Key result
Intensive statins linked to fewer MACCEs vs less intensive therapy in acute MI with LDL <70 mg/dL.
Why the study?
Data on the intensity of statin therapy for patients with acute MI and very low baseline LDL cholesterol level are lacking.
Does more intensive statin therapy reduce major adverse cardiac and cerebrovascular events in patients with acute MI and baseline LDL cholesterol <70 mg/dL?
Cohort (n=1,086)
Yes
Does more intensive statin therapy reduce major adverse cardiac and cerebrovascular events in patients with acute MI and baseline LDL cholesterol <70 mg/dL?
More intensive statin therapy is associated with better clinical outcomes than less intensive statin therapy in acute MI patients even when baseline LDL is already very low (<70 mg/dL).
Intensive statins were associated with lower MACCE in acute MI and LDL <70 mg/dL; leaves open need for randomized confirmation before changing practice.
OBJECTIVE: Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL. METHODS: A total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months. RESULTS: =0.118). CONCLUSION: More intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy.
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Sim et al. (2019) conducted a cohort in Acute myocardial infarction with very low LDL cholesterol (n=1,086). More intensive statin therapy vs. Less intensive statin therapy was evaluated on Major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months. More intensive statin therapy was associated with significantly lower major adverse cardiovascular events compared with less intensive therapy in patients with acute MI and LDL cholesterol <70 mg/dL.
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