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Lyophilisomes—a novel class of nano/microscale capsules—are prepared using a combined freezing, annealing, and lyophilization procedure. Specific molecules could be differentially incorporated in the capsule wall and capsule lumen, thus creating a binary system. With this cheap and simple technology, a large range of new (bioactive) capsules may be anticipated.
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Daamen et al. (2007) studied this question.
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