Design, Synthesis and Molecular Docking Studies of Indolo[2,3-a]Acridinol Derivatives

A study of the synthesis of an indolo [2,3-a]acridinol derivative using the Claisen ester condensation reaction resulted in the discovery of inexpensive and user-friendly solvents.Structures of the newly synthesized compounds were characterized by FT-IR, 1 H NMR, 13 C NMR, and HRMS analyses.Docking studies showed a strong affinity of indolo[2,3a]acridinol towards prostate cancer-related proteins.The binding affinity closer to 10 kcal/mol indicated effective binding.Indolo[2,3-a]acridinol showed strong binding affinities towards protein androgen receptors such a s 1 GS 4 , 1T7R, 2AX8, and 3B66 indicating its potential role in protein kinase inhibition.The programs, AutoDock 4 and Au-toDock Vina, and Swiss ADME software were applied to dock the target protein with synthesized compounds.