What question did this study set out to answer?

Compare national consensus recommendations from the United States and France concerning the clinical management of women with inherited BRCA1 and BRCA2 cancer susceptibilities.

March 1, 1999The LancetOpen Access

Cultural basis for differences between US and French clinical recommendations for women at increased risk of breast and ovarian cancer

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Authors

FEFrançois EisingerInstitut Paoli-Calmettes GGGail GellerJohns Hopkins University WBWylie BurkeRoosevelt University

Discussion

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Implication

Comparative guideline review reveals key divergences in screening and prophylactic surgery for BRCA carriers between the US and France, highlighting cultural influences on medical practice.

Key Points

Compare national consensus recommendations from the United States and France concerning the clinical management of women with inherited BRCA1 and BRCA2 cancer susceptibilities.
Analyzed two major national consensus statements: the US Cancer Genetics Studies Consortium (1997) and the French National Ad Hoc Committee (1998).
Compared clinical management recommendations across surveillance modalities, risk-reducing lifestyle counseling, chemoprevention, and prophylactic surgical procedures.
Guidelines diverged on prophylactic surgery: the US consensus considered informed consent sufficient for mastectomy and oophorectomy, whereas the French consensus deemed informed consent alone insufficient.
Surveillance strategies differed substantially: the US recommended routine breast self-examination and CA-125 ovarian cancer screening, whereas French guidelines did not recommend self-examinations and restricted CA-125 to clinical research.
Recommendations regarding adjunctive interventions varied, with the US advising lifestyle counseling on diet and tobacco, while France established clear positions permitting hormone replacement therapy and hormonal contraception.

Cite This Study

Eisinger et al. (1999) studied this question.

synapsesocial.com/papers/6aaf83cfd89b547592777890 https://doi.org/10.1016/s0140-6736(98)07516-3

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Implication

Comparative guideline review reveals key divergences in screening and prophylactic surgery for BRCA carriers between the US and France, highlighting cultural influences on medical practice.

Cultural basis for differences between US and French clinical recommendations for women at increased risk of breast and ovarian cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Cultural basis for differences between US and French clinical recommendations for women at increased risk of breast and ovarian cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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