Key result
TNF-α -238 GG genotype linked to ~101% greater rheumatoid arthritis susceptibility.
Why the study?
The relationship between TNF-α gene diversity and susceptibility to RA and its clinical phenotypes has been inconsistent in prior studies.
Are TNF-alpha promoter variants associated with susceptibility to rheumatoid arthritis and serum TNF-alpha levels in a south Indian Tamil population?
Population
269 RA patients and 233 healthy controls in a genetically homogeneous south Indian Tamil population
Comparison
TNF-α promoter variants vs healthy controls
Design
Case-control study
Authors
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TNF-α promoter variants may link to RA phenotypes; leaves open clinical utility pending replication in larger cohorts.
Case-Control (n=502)
No
Are TNF-alpha promoter variants associated with susceptibility to rheumatoid arthritis and serum TNF-alpha levels in a south Indian Tamil population?
Odds Ratio: 2.01 (95% CI 1.23–3.29)
Absolute Event Rate: 87% vs 76%
p-value: p=0.004
The TNF-α -238 G allele, -238 GG genotype, and the TNF-α -C-G-G ancestral haplotype may be associated with susceptibility to rheumatoid arthritis in the south Indian Tamil population.
Christina Mary Mariaselvam Salah Sofiane (2014) conducted a case-control in Rheumatoid Arthritis (n=502). TNF-α -238 GG genotype vs. Healthy controls was evaluated on Rheumatoid arthritis susceptibility (frequency of TNF-α -238 GG genotype) (OR 2.01, 95% CI 1.23-3.29, p=0.004). The TNF-α -238 GG genotype was significantly more frequent in patients with rheumatoid arthritis compared to healthy controls (OR 2.01), suggesting it confers susceptibility to the disease.
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