Key result
Lipoprotein lipase gene polymorphisms (D9N, N291S, and S447X) were not significantly associated with the incidence of coronary heart disease or altered lipid profiles in a Sudanese population.
Why the study?
The association of lipid profile with lipoprotein lipase gene polymorphisms and their relation to coronary heart disease in the Sudanese population was unclear.
Is lipoprotein lipase gene polymorphism associated with the incidence of coronary heart disease in a Sudanese population?
Case-Control (n=143)
Is lipoprotein lipase gene polymorphism associated with the incidence of coronary heart disease in a Sudanese population?
Lipoprotein lipase gene polymorphisms (D9N, N291S, S447X) are not associated with the incidence of coronary heart disease in the Sudanese population.
No association seen in Sudanese case-control study; leaves open ancestry-specific LPL effects on CHD risk.
Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol consumption were the most risk factors for early-onset of coronary heart disease (CHD). Sudanese patients had significantly (P<0.05) lower TC and LDL-C levels compared to controls. Allele frequency of LPL D9N, N291S and S447X carrier genotype was 4.2%, 30.7% and 7.1%, respectively. We conclude that lipoprotein lipase polymorphism was not associated with the incidence of CHD in Sudan.
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Hamid et al. (2015) conducted a case-control in Coronary heart disease (n=143). Lipoprotein lipase (LPL) gene polymorphisms (D9N, N291S, S447X) vs. Non-carriers (wild type) was evaluated on Incidence of coronary heart disease and lipid profile variations (p=>0.05). Lipoprotein lipase gene polymorphisms (D9N, N291S, and S447X) were not significantly associated with the incidence of coronary heart disease or altered lipid profiles in a Sudanese population.
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