Key result
Plasma tiRNA-Gln-TTG-001 is overexpressed in children with acute fulminant myocarditis, suggesting potential as a biomarker.
Why the study?
Fulminant myocarditis lacks validated biomarkers and well-established therapy, and the roles of tRNA-derived small RNAs in FM remain unknown.
Are plasma tRNA-derived small RNAs differentially expressed in children with fulminant myocarditis compared to healthy volunteers?
Case-Control
Are plasma tRNA-derived small RNAs differentially expressed in children with fulminant myocarditis compared to healthy volunteers?
tiRNA-Gln-TTG-001 is overexpressed in the acute phase of fulminant myocarditis in children and may serve as a novel biomarker and therapeutic target.
tiRNA-Gln-TTG-001 overexpression in acute pediatric FM is hypothesis-generating; leaves open biomarker or therapeutic utility pending prospective validation.
Aim: Fulminant myocarditis (FM) has neither validated biomarkers nor well-established therapy. Roles of tRNA-derived small RNAs (tsRNAs) in FM remain unknown. Materials & methods: Small RNA sequencing was conducted in plasma from children with FM during acute and convalescent phase and matched healthy volunteers. Data were validated by quantitative real-time PCR in larger sample-sized groups and in vitro. Functional analysis was performed to explore the roles. Results: tiRNA-Gln-TTG-001 was overexpressed in children with FM during acute phase, and the generation and extracellular release of tiRNA-Gln-TTG-001 were higher after myocarditis-mimicked activity in vitro. Several pathways might participate in the pathogenesis of FM. Conclusion: tsRNAs may play an important role in FM, and tiRNA-Gln-TTG-001 might represent a novel and promising biomarker and therapeutic target.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2021) conducted a case-control in Fulminant myocarditis. tiRNA-Gln-TTG-001 expression vs. Matched healthy volunteers was evaluated on Expression levels of tiRNA-Gln-TTG-001. tiRNA-Gln-TTG-001 was overexpressed in the plasma of children with fulminant myocarditis during the acute phase compared to healthy volunteers, suggesting its potential as a biomarker.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: