Key result
Treatment-naïve HIV patients and diabetics had lower LF/HF ratios (0.8 and 0.9) compared to controls (2.3), while HIV patients on HAART showed no difference from controls.
Why the study?
HIV infection can affect cardiac autonomic function, but differences in heart rate variability among HIV patients on HAART, treatment-naïve HIV patients, diabetics, and controls were unclear.
Does highly active antiretroviral therapy (HAART) improve heart rate variability in HIV-infected patients?
Cross-Sectional
Does highly active antiretroviral therapy (HAART) improve heart rate variability in HIV-infected patients?
Answers are grounded in this paper and cite their sources.
HAART may improve cardiac autonomic imbalance in HIV patients, as their heart rate variability frequency domain indices were similar to healthy controls, unlike treatment-naïve HIV patients and diabetics.
HIV infection can affect cardiac autonomic function. We aimed to compare heart rate variability in 29 HIV-infected patients using highly active antiretroviral therapy (HAART), 28 naïve-treatment HIV patients, and diabetics with controls. There was no difference in time index parameters among groups. The normalized power of the low-frequency component (LF) in naïve patients of 39.9 (interquartile interval (IQ), 28.5–65.7) and diabetics of 42.9 (IQ, 14.5–57.7) were decreased compared with controls (67.5, IQ, 37.9–75.4). The normalized power of the high-frequency component (HF) in naïves of 49.7 (IQ, 30.4–64.8), and diabetics of 53.1 (IQ, 34.5–72.2) were increased compared with controls (27.0, IQ, 19.0–57.3). Naïve and diabetics also presented with lower LF/HF ratios (0.8 (IQ, 0.6–2.3), and 0.9 (IQ, 0.3–1.4),) compared with controls (2.3 (IQ, 0.8–3.3)). We can speculate that HAART improves autonomic imbalance in frequency domain indices because there was no difference between the HAART group and controls.
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Benseñor et al. (2011) conducted a cross-sectional in HIV infection and Diabetes. HIV infection (treatment-naïve or on HAART) and diabetes vs. Controls was evaluated on Heart rate variability (LF/HF ratio). Treatment-naïve HIV patients and diabetics had lower LF/HF ratios (0.8 and 0.9) compared to controls (2.3), while HIV patients on HAART showed no difference from controls.
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