Key result
Highly active antiretroviral therapy increased the total power of heart rate variability by 5% (from 1469.9 to 1539.1 ms2) over 12 weeks in patients with HIV infection, compared to a 12% decrease in untreated patients.
Why the study?
The influence of highly active antiretroviral therapy on heart rate variability spectral indices in patients with HIV infection was not well characterized.
Does highly active antiretroviral therapy improve heart rate variability in patients with HIV infection?
Cohort (n=95)
No
Does highly active antiretroviral therapy improve heart rate variability in patients with HIV infection?
Absolute Event Rate: 1539.1% vs 1150.3%
p-value: p=<0.001
Highly active antiretroviral therapy is associated with improved autonomic function and heart rate variability in patients with HIV infection.
HAART-linked HRV gains may reflect autonomic adaptation in HIV; leaves open whether spectral changes predict outcomes or merit monitoring.
Objective: To study the frequency of heart rate variability (HRV) in patients with HIV infection 12 weeks after highly active antiretroviral therapy. Methods: Examined 95 persons aged 24 to 52 years. The main group consisted of 60 patients with HIV infection: 49 men (57.5%) and 11 women (42.5%). The control group included 35 HIV-infected patients of comparable sex and age. A study of the spectral parameters of HRV carried out with the help of the apparatus VARIKARD 2.51 (Russia). Results: After highly active antiretroviral therapy, against the background of improvement in the overall clinical state, HIV-positive patients showed a positive trend from the HRV spectra: total power (TP) increased by 5% (from 1469.9 ± 52.4 up to 1539.1 ± 54.1 ms2) due to an increase in the contribution of the parasympathetic part of the vegetative nervous system. After 3 months of the study, in the patients of the comparison group, against the background of worsening of the overall clinical condition, negative dynamics observed on the part of the HRV frequency parameters. TP decreased by 12% due to increased sympathetic involvement and decreased parasympathetic parts of the vegetative nervous system. Conclusion: The obtained results showed improvement of adaptation processes in HIV-infected patients against the background of highly active antiretroviral therapy.
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N et al. (2017) conducted a cohort in HIV infection (n=95). Highly active antiretroviral therapy (HAART) vs. No HAART was evaluated on Total power (TP) of heart rate variability at 12 weeks (p=<0.001). Highly active antiretroviral therapy increased the total power of heart rate variability by 5% (from 1469.9 to 1539.1 ms2) over 12 weeks in patients with HIV infection, compared to a 12% decrease in untreated patients.
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