Key result
High-dose bovine GH in rats initially elevates then depresses pituitary GH content versus saline.
Why the study?
Large doses of exogenous growth hormone may alter its secretion by the adenohypophysis, but the effects on pituitary GH content in normal rats were not fully characterized.
Does exogenous bovine growth hormone alter pituitary growth hormone content in normal rats?
Does exogenous bovine growth hormone alter pituitary growth hormone content in normal rats?
Answers are grounded in this paper and cite their sources.
Large doses of exogenous growth hormone may alter its secretion by the adenohypophysis in normal rats, demonstrating a feedback mechanism.
Alterations in the content of pituitary GH as estimated by the tibial epi-physeal cartilage assay were produced in rats by the daily, subcutaneous injection of large doses (2 and 6 mg/100 g/day) of bovine GH. An elevation of pituitary GH was observed one day after the first injection of GH. This level returned towards normal after 6 days and the GH content was depressed at 11 days following the initial injection. The injection of saline was without effect on pituitary GH. Blood glucose concentration was slightly elevated at 6 days after the first injection of the higher dose of GH. The rate of weight gain of rats treated with GH was increased. It is suggested that large doses of exogenous GH may alter its secretion by the adenohypophy-sis.
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Krulich et al. (1966) studied Normal rats. Bovine Growth Hormone (GH) vs. Saline was evaluated on Pituitary GH content. Daily subcutaneous injection of large doses of bovine GH in normal rats initially elevated pituitary GH content at 1 day, followed by a depression at 11 days, compared to saline.
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