Key result
Microalbuminuria and macroalbuminuria are linked to higher plasma thrombomodulin versus normoalbuminuria in type 2 diabetes.
Why the study?
Progressive nephropathy in type 2 diabetes is linked to increased albuminuria and cardiovascular risk, with endothelial damage associated with albuminuria but the relationship with circulating markers is unclear.
Are plasma markers of endothelial dysfunction (vWf and TM) elevated in type 2 diabetic patients with microalbuminuria and macroalbuminuria?
Observational (n=90)
Are plasma markers of endothelial dysfunction (vWf and TM) elevated in type 2 diabetic patients with microalbuminuria and macroalbuminuria?
Plasma von Willebrand factor and thrombomodulin are elevated in diabetic nephropathy, suggesting generalized endothelial dysfunction occurs as early as the microalbuminuric stage.
Albuminuria-linked thrombomodulin elevation supports endothelial dysfunction in T2D; hypothesis-generating and leaves open prognostic or therapeutic utility.
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Samy et al. (2012) conducted an observational in Type 2 diabetes (n=90). Microalbuminuria and macroalbuminuria vs. Normal urinary albumin concentration was evaluated on Plasma levels of vonWillebrand factor (vWf) and Thrombomodulin (TM). In patients with type 2 diabetes, microalbuminuria and macroalbuminuria were associated with significantly increased plasma levels of thrombomodulin compared to normoalbuminuria.
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