May 1, 1995Diabetes
Endothelial Dysfunction Precedes Development of Microalbuminuria in IDDM
Why the study?
Does endothelial dysfunction (measured by vWF) precede the development of microalbuminuria in patients with IDDM?
Population
17 patients with insulin-dependent diabetes mellitus and normal urinary albumin excretion at baseline
Design
Cohort
Follow-up
median 64 months (range 51-89)
Authors
Discussion
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Member takes
Implication
Elevated vWF may precede microalbuminuria in type 1 diabetes; hypothesis-generating for endothelial dysfunction but should not yet change practice.
Structured PICO
Does endothelial dysfunction (measured by vWF) precede the development of microalbuminuria in patients with IDDM?
P
Population
17 patients with insulin-dependent diabetes mellitus (IDDM) and normal (< 15 micrograms/min) urinary albumin excretion at baseline
C
Comparator
Patients who maintained normal urinary albumin excretion
O
Outcome
Plasma levels of von Willebrand factor (vWF) and development of microalbuminuriasurrogate
Endothelial dysfunction, indicated by elevated plasma vWF, precedes and may predict the development of microalbuminuria in patients with type 1 diabetes.
Cite This Study
Stehouwer et al. (1995) studied this question.