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March 1, 1995Diabetes Care

Impaired Left Ventricular Diastolic Function and Vascular Postischemic Vasodilation Associated with Microalbuminuria in IDDM Patients

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Why the study?

Is microalbuminuria associated with impaired left ventricular diastolic function and vascular postischemic vasodilation in IDDM patients?

Population

54 subjects total: 34 young long-term insulin-dependent diabetes mellitus patients without hypertension…

Comparison

Presence of microalbuminuria (exposure) vs Absence of microalbuminuria and healthy control…

Design

Cross-sectional

Authors

MGMaria Domenica GuglielmiSPSante D. PierdomenicoLSL. Salvatore

Discussion

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Overview

Microalbuminuria in type 1 diabetes is associated with early subclinical changes in left ventricular morphology, diastolic dysfunction, and impaired vascular dilatory capacity, indicating higher cardiovascular risk.

Structured PICO

Is microalbuminuria associated with impaired left ventricular diastolic function and vascular postischemic vasodilation in IDDM patients?

P
Population
54 subjects total: 34 young long-term insulin-dependent diabetes mellitus (IDDM) patients without hypertension, coronary artery disease, or autonomic dysfunction (16 with microalbuminuria, 18 without), and 20 control subjects.
I
Intervention
Presence of microalbuminuria (exposure)
C
Comparator
Absence of microalbuminuria (normoalbuminuric IDDM patients) and healthy control subjects
O
Outcome
Left ventricular (LV) morphology and function (systolic and diastolic) evaluated by echocardiography, and hyperemic response to forearm ischemia measured by strain-gauge plethysmographysurrogate

Microalbuminuria in type 1 diabetes is associated with early subclinical changes in left ventricular morphology, diastolic dysfunction, and impaired vascular dilatory capacity, indicating higher cardiovascular risk.

Cite This Study

Guglielmi et al. (1995) studied this question.

synapsesocial.com/papers/6a98d28d1c6cd5ba4818e764https://doi.org/10.2337/diacare.18.3.353
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