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November 1, 1998European Heart JournalOpen Access

Increased left ventricular systolic function in insulin dependent diabetic patients with normal albumin excretion

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Why the study?

Does cardiac function differ between insulin-dependent diabetic patients with varying degrees of albuminuria and healthy subjects?

Population

27 insulin-dependent diabetes mellitus patients (grouped by urinary albumin excretion: <20 microg x min…

Design

Cross-sectional

Authors

ECEvald Høj Christiansen

Discussion

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Overview

Hypothesis-generating for hyperdynamic phase preceding microalbuminuria; prospective studies needed before clinical relevance.

Structured PICO

Does cardiac function differ between insulin-dependent diabetic patients with varying degrees of albuminuria and healthy subjects?

P
Population
27 insulin-dependent diabetes mellitus patients (grouped by urinary albumin excretion: <20 microg x min(-1) [normoalbuminuric] and 20 to 200 microg x min(-1) [microalbuminuric]) and 13 healthy subjects. None were or had been treated with cardiovascular drugs.
C
Comparator
13 healthy subjects
O
Outcome
Cardiac function measured by echocardiography (including heart rate, mean velocity of circumferential shortening, stroke velocity index, aortic peak velocity, and diastolic function)surrogate

Cardiac contractility is increased in normoalbuminuric insulin-dependent diabetic patients but normalizes when microalbuminuria develops, suggesting early hyperdynamic cardiac function may precede renal complications.

Cite This Study

Evald Høj Christiansen (1998) studied this question.

synapsesocial.com/papers/6a204f444ad5e85db1e71e8chttps://doi.org/10.1053/euhj.1998.1090
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