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December 12, 2008˜The œNephron journals/Nephron journals

Left Ventricular Diastolic Impairment in Type 1 Diabetic Patients with Microalbuminuria

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Why the study?

Is incipient diabetic nephropathy (microalbuminuria) associated with early diastolic cardiac dysfunction in type 1 diabetic patients?

Population

39 subjects: 13 normotensive type 1 diabetics with incipient nephropathy, 13 type 1 diabetics without…

Design

Cross-sectional

Authors

BWBruno WatschingerMedical University of ViennaCBCh. BrunnerAWA WagnerTechnical University of Munich

Discussion

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Overview

Microalbuminuria was associated with early diastolic impairment in type 1 diabetes; leaves open whether screening or intervention improves outcomes.

Structured PICO

Is incipient diabetic nephropathy (microalbuminuria) associated with early diastolic cardiac dysfunction in type 1 diabetic patients?

P
Population
39 subjects: 13 normotensive type 1 diabetics with incipient nephropathy (microalbuminuria > 30 mg/day, mean age 37.8 +/- 3.5, diabetes duration 18.8 +/- 2.6 years), 13 type 1 diabetics without nephropathy (matched for age, diabetes duration and metabolic control), and 13 normal controls. Diseases known to affect left ventricular performance were ruled out.
C
Comparator
Type 1 diabetics without nephropathy and normal controls
O
Outcome
Right and left ventricular parameters assessed by M-mode and Doppler echocardiography (systolic and diastolic function)surrogate

Type 1 diabetic patients with microalbuminuria exhibit early left ventricular diastolic impairment despite normal systolic function.

Cite This Study

Watschinger et al. (2008) studied this question.

synapsesocial.com/papers/6a7e74b5fff18652e232fd1chttps://doi.org/10.1159/000187173
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