Key result
Type 2 diabetes mellitus was associated with a significant reduction in average peak systolic left ventricular global longitudinal strain compared to controls (-16.18% vs -18.13%), which significantly correlated with albumin-creatinine ratio in patients with albuminuria (r = 0.55).
Why the study?
Type 2 diabetes mellitus insidiously affects the myocardium and causes microvascular renal damage reflected by albuminuria, but the relationship between albuminuria and subclinical left ventricular systolic dysfunction in asymptomatic normotensive patients was unclear.
Does albuminuria correlate with subclinical left ventricular systolic dysfunction in asymptomatic normotensive patients with Type 2 Diabetes Mellitus?
Observational (n=90)
Single-blind
No
Does albuminuria correlate with subclinical left ventricular systolic dysfunction in asymptomatic normotensive patients with Type 2 Diabetes Mellitus?
Absolute Event Rate: -16.18% vs -18.13%
p-value: p=<0.001
In asymptomatic normotensive patients with T2DM, albuminuria correlates with subclinical left ventricular systolic dysfunction as measured by global longitudinal strain, suggesting parallel microvascular and myocardial disease progression.
GLS reduction may signal subclinical dysfunction in T2DM with albuminuria; leaves open prospective validation before clinical adoption.
Background: Type 2 diabetes mellitus (T2DM) insidiously affects the myocardium with subsequent cardiomyopathy and induces microvascular damage in the kidneys reflected by albuminuria. We aimed to investigate the relationship between albuminuria and subclinical left ventricular (LV) systolic dysfunction in asymptomatic normotensive patients with T2DM assessed by two-dimensional speckle-tracking echocardiography. Materials and Methods and Results: Sixty normotensive patients with T2DM were included and subdivided into two subgroups, each including thirty patients according to the presence of albuminuria, together with thirty control subjects. All underwent echocardiographic examination, including LV regional and global longitudinal strain (GLS) measurements. Laboratory tests were withdrawn, including serum glycated hemoglobin (HbA1C) and albumin–creatinine ratio (ACR). When compared to the control group, patients with T2DM had a significantly lower average peak systolic LV GLS (−16.18% ± 2.78% vs. −18.13% ± 2.86%, P < 0.001), however, there was no significant difference in average peak systolic LV GLS between both diabetic subgroups (−15.57% ± 2.77% in the albuminuric subgroup vs. −16.79% ± 2.70% in the nonalbuminuric subgroup, P = 0.077). Moreover, there was a significant correlation between ACR and reduction of GLS in patients with T2DM and albuminuria ( r = 0.55, P = 0.002). However, this correlation was absent in patients with T2DM without albuminuria ( r = 0.107, P = 0.573). Conclusions: Patients with T2DM have subclinical LV systolic dysfunction with a reduction of average LV GLS that correlates with ACR in patients with T2DM and albuminuria.
No takes yet. Share an insight, caveat, or question.
Abdellatif et al. (2021) conducted an observational in Type 2 Diabetes Mellitus (n=90). Type 2 Diabetes Mellitus and Albuminuria vs. Healthy controls and non-albuminuric T2DM patients was evaluated on Average peak systolic left ventricular global longitudinal strain (GLS) (p=<0.001). Type 2 diabetes mellitus was associated with a significant reduction in average peak systolic left ventricular global longitudinal strain compared to controls (-16.18% vs -18.13%), which significantly correlated with albumin-creatinine ratio in patients with albuminuria (r = 0.55).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: